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THE ROLE OF DAP-KINASE IN MODULATING VASCULAR ENDOTHELIAL CELL FUNCTION UNDER FLUID SHEAR STRESS
DAP-K Mechano-transduction Apoptosis Shear Atherosclerosis
2015/1/12
Atherosclerosis preferentially develops in vascular regions of low or disturbed flow and high spatial gradients. Endothelial cells that line the vessel walls actively participate in translating mechan...
Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF
TrkB Alzheimer BACE1 SHC NFAT
2013/1/28
Brain derived neurotrophic factor (BDNF) levels and signaling via the tyrosine receptor kinase B (TrkB) have been shown to be altered in Alzheimer’s Disease. In addition, it has been reported that the...
Fms-like tyrosine kinase (Flt)-4 signaling participates in osteoclast differentiation in osteopetrotic (op/op) mice
Fms-like tyrosine kinase (Flt)-4 osteoclast differentiation osteopetrotic (op/op) mice
2009/5/8
Vascular endothelial growth factor (VEGF) induces osteoclast differentiation as well as neovascularization by binding to the fms-like tyrosine kinase (Flt)-1 and fetal liver kinase (Flk)-1 receptors...
Role of Raf-1 kinase in Diabetes-induced Accelerated Apoptosis of Retinal Capillary Cells
apoptosis diabetic retinopathy endothelial cells Raf-1 small molecular weight G-protein
2009/4/29
Small molecular weight G-proteins serve as fundamental signaling switches that regulate cell fates by coupling receptor activation to downstream effector pathways. H-Ras, a small molecular weight G-pr...
Integrin-linked Kinase：It's Role in the Vascular System
integrin-linked kinase vascular biology blood vessel endothelium
2009/4/20
Integrin-linked kinase (ILK) is an intracellular molecule that binds to the cytoplasmic domain of β1 and β3-integrin. It has been previously demonstrated in various epithelial cell lines to mediate th...
Influence of 2-methoxyestradiol on cell morphology and Cdc2 Kinase activity in WHCO3 esophageal carcinoma cells
2-methoxyestradiol cell morphology Cdc2 Kinase activity WHCO3 esophageal carcinoma cells
2009/3/2
The influence of 1 × 10-6 M exogenous 2-methoxyestradiol (2ME) was investigated on nuclear and cytoplasmic morphology, as well as Cdc (cell division cycle) 2 kinase activity in WHCO3 esophageal carc...