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同济大学医学院附属同济医院吴登龙教授团队阐明前列腺癌精准化治疗新策略，研究成果在线发表于“Molecular Cell”（图）
同济大学医学院附属同济医院 吴登龙教授 阐明 前列腺癌 治疗 研究成果 Molecular Cell
2020/10/28
前列腺癌是目前全世界男性第二大癌症相关致死性疾病。近年来我国前列腺癌的发病率呈显著增长趋势，严重威胁老年男性生命健康。前列腺癌中TMPRSS2-ERG 基因融合现象十分常见，其在欧美人群中发生率高达50%，在亚洲人群中也占据约四分之一。TMPRSS2-ERG 基因融合导致 ERG 致癌蛋白异常高表达，ERG 致癌蛋白作为恶性促癌转录因子进一步激活下游一系列致癌基因及其表达的致癌蛋白，从而促进前列腺...
Development of transmembrane signaling in the fetal rat Leydig cell
transmembrane signaling fetal rat Leydig cell
2009/2/23
Gonadotropin binding to the adult Leydig cell activates a GTP binding protein that interacts with adenylate cyclase to increase cAMP production within the cell. The increased production of cAMP stim...
Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate（EDS）can take place in the absence of LH
proliferation differentiation Leydig cell precursors
2009/2/23
In hypophysectomized rats, 2 days after the administration of the cytotoxic drug ethane dimethyl sulphonate (EDS), the proliferative activity of Leydig cell precursors increased six-fold. Thus, fact...
The differential effects of the indazole-carboxylic acid derivative, tolnidamine, on Sertoli cell protein secretion
Indazole-carboxylic acids tolnidamine antispermatogenic agents Sertoli cell
2009/2/23
The indazole-carboxylic acid derivative tolnidamine (TOL) has marked antispermatogenic activity in rats. Previous morphological and biochemical studies indicate that Sertoli cells are one of the tar...
Leydig cell and extracellular matrix effects on Sertoli cell function：biochemical and morphologic studies
Leydig cell extracellular matrix Sertoli cell function
2009/2/23
The reciprocal influence between Leydig and Sertoli cells prepared from pig testis were studied by coculture of both types of cells in either plastic dishes or dishes coated with basement membrane...
The action of calcitonin on the TM4 Sertoli cell line and on rat Sertoli cell-enriched cultures
TM4 Sertoli cell line rat Sertoli cell-enriched cultures
2009/2/23
The effects of synthetic salmon calcitonin on primary Sertoli cell-enriched cultures and on an established cell line (TM4 cells, derived from immature mouse Sertoli cells) were studied. Synthetic ...
The actions of calcitonin on the TM3 Leydig cell line and on rat Leydig cell-enriched cultures
calcitonin TM3 Leydig cell line rat Leydig cell-enriched cultures
2009/2/23
Studies demonstrating calcitonin receptors on Leydig cells have suggested that these cells may be one of the many sites affected by this peptide. To investigate this possibility, the effect of syn...
The changing profiles of L-ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase activities in testicular cell types during sexual maturation of male rats
L-ornithine decarboxylase S-adenosyl-L-methionine testicular cell types
2009/2/23
To understand the involvement of polyamines in testicular maturation and spermatogenesis, the activity of two enzymes involved in the polyamine synthetic pathway, L-ornithine decarboxylase (ODC) a...
Transferrin secretion in response to different modes of FSH stimulation and cycloheximide in superfused Sertoli cell cultures
Transferrin secretion FSH stimulation cycloheximide superfused Sertoli cell cultures
2009/2/23
The influence of different modes of FSH stimulation and cycloheximide on transferrin secretion by rat Sertoli cells was investigated using a superfusion culture system. Sertoli cells from 18-day-old...
The regulation of the proliferation and differentiation of rat Leydig cell precursor cells after EDS administration or daily HCG treatment
Leydig cell Leydig cell precursor LH hCG EDS proliferation
2009/2/23
The proliferation and differentiation of possible Leydig cell precursors in adult rats were studied after destruction of the existing Leydig cells with EDS or after daily treatment with hCG. After 2...
Variation in the effect of a nongonadotropic Leydig cell stimulating factor in testicular interstitial fluid after exposure of the testis to a single episode of heat treatment
Variation nongonadotropic Leydig cell testicular interstitial fluid testis
2009/2/23
The activity of a nongonadotropic factor present in rat testicular interstitial fluid and capable of stimulating Leydig cell testosterone production was measured at intervals for 8 weeks after exp...
Follicle stimulating hormone, luteinizing hormone and testicular Leydig cell responses to estradiol immunization in Ile-de-France rams
Follicle stimulating hormone luteinizing hormone testicular Leydig cell estradiol immunization Ile-de-France rams
2009/2/23
Active immunization of Ile-de-France rams against estradiol (E2) resulted in the production of E2-neutralizing antibodies and an elevation in the plasma concentrations of FSH, LH, and testosterone...
Evidence for age-dependent changes in Sertoli cell androgen receptor concentration
age-dependent changes Sertoli cell receptor concentration
2009/2/23
Cytosol and nuclear receptor concentrations in Sertoli cells isolated from the testes of 15-, 25-, and 35-day-old rats were measured using hydroxylapatite separation procedures. In these cells the m...
Decrease in the number of human Ap and Ad spermatogonia and in the Ap/ Ad ratio with advancing age. New data on the spermatogonial stem cell
human testis spermatogonia aging
2009/2/23
The numbers of Ap and Ad spermatogonia per unit section of the testis were calculated in autopsy specimens from young adults and elderly men without testicular pathology. The number of Ap spermatogo...
Transferrin-mediated transcellular transport of 59Fe across confluent epithelial sheets of Sertoli cells grown in bicameral cell culture chambers
Transferrin-mediated transcellular transport 59Fe Sertoli cells bicameral cell
2009/2/23
The transferrin-mediated transcellular transport of 59Fe across confluent epithelial sheets of Sertoli cells grown on Millipore filters was investigated. These filters had been impregnated with reco...