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Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss
browning exercise microarray obesity weight loss white adipose tissue
2018/12/13
Background: A hypothesis exists whereby an exercise- or dietary-induced negative energy balance reduces human subcutaneous white adipose tissue (scWAT) mass through the formation of brown-like adipocy...
Serum response factor-dependent regulation of smooth muscle gene transcription
Smooth muscle cells Gene regulation MicroRNA Chromatin remodeling Serum Response Factor
2015/5/22
Several common diseases such as atherosclerosis, post-angioplasty restenosis, and graft vasculopathies, are associated with the changes in the structure and function of smooth muscle cells. During the...
Novel regulation of neuronal genes implicated in Alzheimer disease by microRNA
Alzheimer APP BACE1 microRNA post-transcriptional gene regulation amyloid fetal neurons
2015/5/21
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β peptide (Aβ) as neuritic plaques in the brain. The short Aβ peptide is derived from a large transmembrane precurs...
EVALUATION OF GENE REGULATION AND THERAPEUTIC DRUGS RELATED TO ALZHEIMER’S DISEASE IN DEGENERATING PRIMARY CEREBROCORTICAL CULTURES
Alzheimer synapse neurodegeneration primary culture memantine
2015/5/21
Alzheimer’s disease (AD) is a neurological disorder defined by the presence of plaques comprised mostly of amyloid-β (Aβ), and neurofibrillary tangles consisting of hyperphosphorylated microtubule ass...