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Glycogen is a major energy reserve in most eukaryotes and its rate of synthesis is controlled by glycogen synthase. The activity of eukaryotic glycogen synthase is regulated by the allosteric activato...
Regulation of SRF Activity by the ATP-dependent Chromatin Remodeling Enzyme, CHD8
chromatin remodeling SRF apoptosis
2015/5/22
Under normal conditions, smooth muscle cells do not replicate, or proliferate, and provide a means of contraction for many internal organs, including blood vessels and the gut. However, under abnormal...
Mechanisms of translational regulation in the pancreatic β cell stress response
Diabetes Islet ER stress Pdx1
2015/5/22
The islet beta cell is unique in its ability to synthesize and secrete insulin for use in the body. A number of factors including proinflammatory cytokines, free fatty acids, and islet amyloid are kno...
CONTRIBUTION OF RANKL REGULATION TO BONE RESORPTION INDUCED BY PTH RECEPTOR ACTIVATION IN OSTEOCYTES
RANKL REGULATION CONTRIBUTION
2015/5/21
PTH increases osteoclasts by upregulating RANKL in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell remains undefined. Recent findings demonstrate that P...
DYS-REGULATION OF EXTRACELLULAR MATRIX PROTEINS TURNOVER BY HIGH GLUCOSE CONCENTRATIONS IN CULTURED HUMAN GLOMERULAR MESANGIAL CELLS
Fibronectin Collagen
2010/4/27
Diabetic glomerulopathy is generally believed to be the major cause for the development of chronic renal failure in diabetes mellitus. Diabetic glomerulosclerosis is characterized by the accumulation ...