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Accurate prediction of gene expression by integration of DNA sequence statistics with detailed modeling of transcription regulation
gene expression DNA sequence statistics detailed modeling transcription regulation
2011/1/5
Gene regulation involves a hierarchy of events that extend from specific protein-DNA interactions to the combinatorial assembly of nucleoprotein complexes. The effects of DNA sequence on these process...
Classification of Saccharomyces cerevisiae promoter regions into distinct chromatin classes reveals the existence of nucleosome-depleted hotspots of transcription factor occupancy
Classification Saccharomyces cerevisiae promoter regions distinct chromatin classes existence nucleosome-depleted hotspots factor occupancy
2010/11/15
Transcription factors (TF) play an essential role in the cell as locus- and condition-specific recruiters of transcriptional machinery or chromatin-modifying complexes. However, predicting the in vivo...