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Genomic differences selected through evolution may offer clues as to why COVID-19 outcomes vary widely（图）
基因组差异 病毒学 COVID-19
2023/7/11
Though underlying medical conditions play an important role, many aspects of why COVID-19 severity can differ vastly from one person to another have remained unclear.
Prospective associations of maternal betaine status with offspring weight and body composition at birth: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study
betaine pregnancy birth weight infants adiposity
2018/12/18
Background: Betaine supplementation results in lower body weight and fat mass and higher lean mass in animals and adult humans. However, the relation between maternal betaine status and offspring birt...
Serum 25-hydroxyvitamin D concentrations and treatment outcomes of women undergoing assisted reproduction
vitamin D infertility assisted reproductive technologies epidemiology nutrition
2018/12/14
Background: Vitamin D deficiency impairs fertility in animal models, but the role of vitamin D in human fertility or treatment of infertility is less clear.
Predicting successful long-term weight loss from short-term weight-loss outcomes: new insights from a dynamic energy balance model (the POUNDS Lost study)
dynamic model energy balance receiver operating characteristic weight loss mathematical model likelihood function regression
2018/12/24
Background: Currently, early weight-loss predictions of long-term weight-loss success rely on fixed percent-weight-loss thresholds.
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver iver enzymes GDM fatty liver ransaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver liver enzymes GDM fatty liver transaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid
L-ascorbic acid cardiometabolic traits confounding genetic variants reverse causation
2018/12/20
Background: Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and re...
Brain mapping study to improve outcomes for preterm infants（图）
Brain mapping preterm infants
2014/7/10
A University of Queensland study into how premature babies’ brains develop will lead to the earlier diagnosis of brain impairment in preterm children.
Effects of IFN-γ on IL-18 Expression in Pregnant Rats and Pregnancy Outcomes
Interleukin-18 Interferon-γ Pregnant Rat Immunohistochemistry Uterus Abortion
2016/5/12
The present study focused on establishing the effects of interferon-gamma (IFN-γ) on interleukin-18 (IL-18) expression patterns and pregnancy outcomes in pregnant rats. Pregnant rats at the post-impla...