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Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Angiotensin I-Converting Enzyme Inhibitor Activity on Egg Albumen Fermentation
Functional Food Angiotensin I-Converting Enzyme Inhibitor Activity
2016/5/18
Lactobacillus plantarum is used for fermentation of fish products, meat and milk. However, the utilization of these bacteria in egg processing has not been done. This study was designed to evaluate th...
TRAF-interacting protein, an inhibitor of the canonical nuclear factor-kappaB pathway, plays a key role in the estradiol -dependent apoptosis of the dual-phenotype gamma amino butyric acid/glutamate neurons in the anteroventral periventricular nucleus of the male rat
Mediated estradiol LH surge neurons male AVPV E2 - mediated cell death neurons
2014/12/11
The anteroventral periventricular nucleus (AVPV) of the preoptic area mediates the positive feedback effects of estradiol (E2) on LH surge in rats. Consistent with their role in female reproduction, t...
Wnt signaling in zebrafish fin regeneration : chemical biology using a GSK3β inhibitor
zebrafish Wnt regeneration bone
2015/5/22
Bone growth can be impaired due to disease, such as osteoporosis. Currently, intermittent parathyroid hormone (PTH) treatment is the only approved therapy in the United States for anabolic bone growth...
THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3
p34Cdc2 Survivin Wee1 Caspase-3 Apoptosis
2015/5/21
The anti-apoptotic protein Survivin and the cyclin-dependent kinase p34Cdc2 are involved in cell cycle progression and apoptosis. Activation of Cdc2 is required for its pro-apoptotic activity, which c...
Use of Chemical Treatments to Reduce Tannins and Trypsin Inhibitor Contents in Salseed (Shorea robusta) Meal
Trypsin Inhibitor Condensed Tannins Hydrolysable Tannins
2016/5/3
This study investigated the effect of chemical treatments on tannins (condensed and hydrolysable) and on the trypsin inhibitor (TI) activity in salseed meal. Triplicate samples of ground salseed meal ...
GLOBAL SOLUTIONS AND BLOW UP FOR ACTIVATOR INHIBITOR MODEL
Global solutions blow up of solution a
2007/8/7
This paper deals with the existence and nonexistence of global positive solutions of initial and boundary value problem for the general activator-inhibitor model... In this paper, we do not restrict ...
专著信息
书名
Identification and cloning of a trypsin inhibitor from skin secretions of Chinese red belly toad Bombina maxima
语种
英文
撰写或编译
作者
Lai Ren,Liu Hen,Lee Wen-Hui,Zhang Yun
第一作者单位
出版社
Comp. Biochem. P...
专著信息
书名
Characterization and molecular cloning of frog albumin from Bombina maxima skin, a novel potent serine protease inhibitor
语种
英文
撰写或编译
作者
Ying-Xia Zhang,Wen-Hui Lee,Ren Lai,Yun Zhang
第一作者单位
出版社...
期刊信息
篇名
In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects.
语种
英文
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撰写
作者
Guo XN.,Zhong L.,Tan JZ.,Li J.,Lu...
期刊信息
篇名
Effects of 17β-estradiol on the expression of matrix Metalloproteinase-1, -2 and tissue inhibitor of metalloproteinase-1 in human osteoblast-like cells cultures
语种
英文
撰写或编译
作者
廖二元, 罗湘杭
第一作者单位
...
Use of Chemical Treatments to Reduce Tannins and Trypsin Inhibitor Contents in Salseed (Shorea robusta) Meal
Trypsin Inhibitor Condensed Tannins Hydrolysable Tannins
2016/4/26
This study investigated the effect of chemical treatments on tannins (condensed and hydrolysable) and on the trypsin inhibitor (TI) activity in salseed meal. Triplicate samples of ground salseed meal ...
Assessment of the Sensitivity and Death Rates of Adults of Graphosoma lineatum (Linnaeus, 1758) Fed Chlorocholine Chloride, a Plant Growth Inhibitor, Under Laboratory Conditions
Graphosoma lineatum adults chlorocholine chloride sensitivity death rates
2010/3/29
The side effects of chlorocholine chloride, a plant growth inhibitor, on adults of Graphosoma lineatum were studied under laboratory conditions. In the study, 100, 250, 500, 750, 1000 and 1500 ppm of ...
Increased vasoconstricti on to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-in duced diabetes
Capacitance Mean circulatory filling pressure Noradrenaline Vasoconstrictio
2014/3/31
There is evidence that inducible nitric oxide synthase (iNOS) is activated at the acute phase of diabetes. We examined if selective
inh ibitio n of iNOS by 1400W ( N -3-amino methyl -benz yl- acetami...
Influence of the Novel Urease Inhibitor Hydroquinone on Growing Lamb Nitrogen Utilization
Hydroquinone Urea Nitrogen Utilization Lamb
2016/4/11
Two in vivo experiments were conducted to evaluate the effect of novel urease inhibitor hydroquinone (HQ) on ammonia release rate from urea hydrolysis, nitrogen balance, nutrient digestibility and eff...