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探讨细胞色素P4502D6（CYP2D6）和多巴胺D2受体（DRD2）基因多态性及其交互作用与阿立哌唑治疗精神分裂症临床疗效的关联。方法选取120例接受单一阿立哌唑治疗4周的精神分裂症住院患者为研究对象，采用4周末阳性与阴性症状量表（PANSS）减分率评定药物疗效，其中有效（≥50%）组69例，无效（＜50%）组51例。采用多重高温连接酶检测反应技术检测CYP2D6（rs1065852、rs113...
MECHANISMS OF VARIABILITY IN CYP2D6 METABOLISM: THE CONTRIBUTIONS OF POLYMORPHISMS, COPY NUMBER VARIATIONS AND microRNA
COPY NUMBER VARIATIONS microRNA
2015/5/21
Cytochrome P450 2D6 (CYP2D6) is an important drug metabolizing enzyme that is involved in the metabolism of 20-25% of commonly prescribed drugs. There is interindividual variability in CYP2D6 enzyme a...