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Peripheral neuropathy risk and a transcobalamin polymorphism: connecting the dots between excessive folate intake and disease susceptibility
Peripheral neuropathy risk a transcobalamin polymorphism dot disease susceptibility
2018/12/19
Advances in the broad field of nutritional genomics continue to shed light on variable disease susceptibility to modifications in micronutrient intake within populations. This is certainly the case wi...
Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
folate folic acid peripheral neuropathy TCN2 776C>G polymorphism transcobalamin vitamin B-12
2018/12/19
Background: The 776C→G polymorphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is associated with a lower holotranscobalamin concentration in plasma. This ...
Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status1,2,3
Transcobalamin holo-transcobalamin holo-TC vitamin B-12 vitamin B-12 absorption
2008/12/11
Background:It has been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be used to assess absorption. To develop a reliable clinical absorption test that uses h...