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Joint Modeling and Clustering Paired Generalized Longitudinal Trajectories with Application to Cocaine Abuse Treatment Data
Clustering Functional data analysis Exponential family Joint modeling
2016/1/26
In a cocaine dependence treatment study, we have paired binary longitudinal tra-jectories that record the cocaine use patterns of each patient before and after a treat-ment. To better understand the d...
Joint Modeling and Clustering Paired Generalized Longitudinal Trajectories with Application to Cocaine Abuse Treatment Data
Clustering functional data analysis exponential family joint modeling EM algorithm
2016/1/20
In a cocaine dependence treatment study, we have paired binary longitudinal tra-jectories that record the cocaine use patterns of each patient before and after a treat-ment. To better understand the d...
A Comparison of Dexmedetomidine, Moxonidine and Alpha-Methyldopa Effects on Acute, Lethal Cocaine Toxicity
Cocaine Intoxication Dexmedetomidine Moxonidine Alpha-Methyldopa
2015/11/6
Background: The treatment of cocaine toxicity is an important subject for emergency physicians. We investigated the effects of dexmedetomidine, moxonidine and alpha-methyldopa on acute cocaine toxicit...
Chronic Ethanol Drinking by Alcohol-preferring Rats Increases the Sensitivity of the Mesolimbic Dopamine System to the Reinforcing and Stimulating Effects of Cocaine
alcohol ethanol cocaine dopamine mesolimbic nucleus accumbens ventral tegmental area VTA rat alcohol-preferring microdialysis intracranial ICSA
2015/1/9
Alcohol and cocaine are commonly co-abused drugs, and those meeting criteria for both cocaine and alcohol use disorders experience more severe behavioral and health consequences than those with a sing...
Neuroadaptations and Behavioral Profiles Associated with Cocaine Self-Administration in Rhesus Monkeys (Macaca Mulatta)
Biological sciences Psychology Addiction Behavior Gaba Immunohistochemistry In situ hybridization Monkey
2014/11/4
Cocaine abuse and addiction are widespread problems with profound medical and socioeconomic consequences. At present, the neurobiological adaptations associated with short- and long-term cocaine abuse...
Khat: Is It More Like Coffee or Cocaine? Criminalizing a Commodity, Targeting a Community
Cathinone Drugs Terrorism Immigration Traditional Use Law Enforcement
2013/2/19
This article looks at the expansion of khat chewing from the Horn of Africa to Western countries. It assesses the reaction of various sections of US society toward a practice they perceived as a dange...
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine
mGluR5 Knockout mice normal conditioned place-preference cocaine Neurons and Cognition
2012/4/28
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice fo...
Khat: Is It More Like Coffee or Cocaine? Criminalizing a Commodity, Targeting a Community
Cathinone Drugs Terrorism Immigration Traditional Use
2013/9/5
This article looks at the expansion of khat chewing from the Horn of Africa to Western countries. It assesses the reaction of various sections of US society toward a practice they perceived as a dange...
After experiencing a period of rapid decline between 1986 and 1994, cocaine use is once again on the rise in the United States. The increased prevalence of use among college students is particularly t...
Design of Cocaethylene and Cocaine conjugates to produce highly selective Polyclonal Antibodies
cocaine cocaethylene benzoylecgonine hapten antibody
2009/4/20
With the aim to obtain specific anti-cocaine antibodies directed against cocaine and active metabolites for use in immunotherapy, a series of six haptens were prepared, based on the structure of ...
Effects of cocaine hydrochloride on reproductive function and sexual behavior of male rats and on the behavior of their offspring
cocaine hydrochloride reproductive function sexual behavior male rats offspring
2009/2/23
Cocaine hydrochloride (30, 15, or 0 mg/kg) was administered daily subcutaneously to male rats for a minimum of 72 days. Animals receiving the 15-mg/kg and 0-mg/kg doses were pair-fed with animals re...
The Association Between Maternal Cocaine Use During Pregnancy and Physiological Regulation in 4- to 8-Week-Old Infants: An Examination of Possible Mediators and Moderators
heart rate prenatal cocaine exposure regulation respiratory sinus arrhythmia
2008/4/8
Objective To examine the association between maternal cocaine use during pregnancy and physiological measures of regulation, which included heart rate (HR) and respiratory sinus arrhythmia (RSA). Meth...
Outcome from a Prospective, Longitudinal Study of Prenatal Cocaine Use: Preschool Development at 3 Years of Age
prenatal cocaine use preschool development structural equation modeling
2008/4/8
Objective To determine the effects of prenatal cocaine exposure on child development. Methods This prospective, longitudinal study recruited 154 pregnant cocaine users who were matched on race, parity...
Mental Health Outcomes of Cocaine-Exposed Children at 6 Years of Age
ADHD adoptive or foster care CBCL Dominic Interactive mental health outcomes oppositional defiant disorder prenatal cocaine exposure
2008/4/8
Objective To assess 6-year-old cocaine- and noncocaine-exposed children’s mental health outcomes controlling for potential confounders. Methods The sample consisted of 322 children [169 cocaine expose...
Aggression at Age 5 as a Function of Prenatal Exposure to Cocaine, Gender, and Environmental Risk
aggression cocaine exposure environmental risk
2008/3/25
Objective To examine childhood aggression at age 5 in a multiple risk model that includes cocaine exposure, environmental risk, and gender as predictors. Methods Aggression was assessed in 206 childre...