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Individual CDR3 Regions as Targets for Detection of Clonal Cells in Acute Lymphocytic Leukemia
Minimal residual disease Acute lymphocytic leukemia CDR3
2009/6/26
Immunoglobulin heavy chain rearrangements provide a specific identity of complementarity determining region 3 (CDR3) DNA sequences. For this reason, CDR3 regions may be used in the diagnosis of malign...
Jurkat 细胞TCR 基因重排对BV CDR3的影响
2007/7/25
TCRβ链可变区互补决定区3 (TCR BV CDR3)是TCRβ链胚系基因片段重排过程中,由BV末端、BD片段、BJ前端以及重排时V-D与D-J之间的插入序列组成 (VNDNJ),对抗原的特异性识别发挥主要作用[1],[2]。不同克隆T细胞TCR CDR3长度及序列有所不同 。目前报道,TCRBV 基因有26个亚家族,通过设计各家族上游引物和TCR BC下游引物,利用RT-PCR可扩增出特异性T...