搜索结果: 1-15 共查到“临床医学 receptor”相关记录39条 . 查询时间(0.25 秒)
Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons
NMDA receptor BDNF neurotrophins
2015/7/28
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathol...
Serotonin receptor is involved in eczema and other itch conditions
Serotonin receptor eczema other itch conditions
2015/6/18
Dermatologists have long known that available treatments for chronic itch, including eczema, are simply not up to scratch. But scientists have now discovered a new gene that promotes itch, suggesting ...
The role of high mobility group box 1 and toll like receptor 4 in a rodent model of neuropathic pain
HMGB1 TLR4 Neuropathic Pain
2015/5/21
Neuropathic pain is a serious health problem that greatly impairs quality of life. The International Association for the Study of Pain (IASP) defines neuropathic pain as ‘pain arising as a direct cons...
Lack of EGF receptor contributes to drug sensitivity of human germline cells
DNA damage epidermal growth factor receptor drug resistance
2014/12/12
Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Alt...
Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
APE1 Ref-1
2014/12/12
Apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) is involved both in the base excision repair (BER) of DNA lesions and in the eukaryotic transcriptional regulation. APE1/Ref-1 i...
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcγIIA receptor–induced phagocytosis
NADPH oxidase phagocytosis
2014/12/12
Superoxide produced by the phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is essential for host defense. Enzyme activation requires translocation of p67phox, p47phox, an...
Serum Lectin-Like Oxidized-Low Density Lipoprotein Receptor-1 and Adiponectin Levels Are Associated With Coronary Artery Disease Accompanied With Metabolic Syndrome
LOX-1 Coronary Artery Disease Adiponectin Metabolic Syndrome
2015/10/14
Background: Coronary artery disease (CAD) is a major public health problem for developed and developing countries and is the single leading cause of death worldwide.
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis Inflammation Antigen-Induced Arthritis Mouse Mod-el Monocytes/Macrophages
2013/1/31
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
Antitussive Effects of the Leukotriene Receptor Antagonist Montelukast in Patients with Cough Variant Asthma and Atopic Cough
atopic cough cough score cough variant asthma leukotriene receptor antagonist montelukast
2010/11/12
In patients with CVA, 2-week treatment with montelukast, clenbuterol, and montelukast plus clenbuterol all significantly decreased cough scores and treatment with montelukast plus clenbuterol was supe...
The effect of AT1 receptor blockade on bax and bcl-2 expression in bleomycin-induced pulmonary fibrosis
bcl-2 bax bleomycin pulmonary fibrosis losartan
2009/12/14
ABSTRACT
Background and the purpose of the study: Recent studies have indicated the role of apoptosis and angiotensin in the pathogenesis of bleomycin induced-pulmonary fibrosis. Losartan, an angiote...
目的: 分析幽门螺杆菌(H pylori)感染对胃黏膜癌变过程中胃泌素及受体CCK-BR基因转录和蛋白表达的影响，探讨H pylor在胃癌发生中的作用. 方法: 采用快速尿素酶试验、Giemsa染色及Warthin-Starry银染色检测H pylori;应用免疫组织化学和RT-PCR技术检测萎缩性胃炎51例，18例肠上皮化生18例，异型增生15例和胃癌组织37例中的胃泌素及受体CCK-BR蛋白和...
Disseminated Mycobacterium Fortuitum- Chelonae Complex Infection in a Child With IL-12 Receptor Deficiency
Mycobacterium fortuitumchelonae complex interleukin-12 receptor deficiency interferon-gamma
2009/6/30
Protective immunity to bacteriae that can multiply intracellularly such as mycobacterium and salmonella is known to depend on cell-mediated immunity (1). The major effector mechanism of cell-mediated ...
Effects of ACE Inhibition and AT1 Receptor Blockade on Cardiac Ischaemia-Reperfusion Induced Mortality and Cardiac Markers in Rats
Myocardial Ischemia-Reperfusion Arrhythima Cardiac Marker Troponin Captopril Losartan
2009/6/22
Many studies have established the therapeutic benefits of angiotensin-converting enzyme (ACE) inhibitors such as reducing reperfusion arrhythmias, and angiotensin II type 1 (AT1) blocker may have simi...
TaqI Polymorphism of the Vitamin-D Receptor Gene and Quality of Life in Postmenopausal Turkish Women
Osteoporosis quality of life TaqI polymorphism vitamin D receptor gene
2009/6/16
Aim: We aimed to assess vitamin-D receptor (VDR) gene polymorphism in postmenopausal osteoporotic Turkish women as well as the impact of this on diagnosis, treatment and quality of life. Materials and...
Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice
allergic rhinitis eosinophils murine model ovalbumin
2010/11/16
Background: Peroxisome proliferator-activated receptor γ(PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosin...