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Every day, billions of red blood cells pass through the spleen, an organ that is responsible for filtering out old or damaged blood cells. This task is made more difficult when the blood cells are mis...
Nitric Oxide and Trace Metals in Relation to Haemoglobin F Concentration in Nigerian Sickle Cell Disease Patients
Sickle cell disease trace metals haemoglobin F oxidants
2010/2/24
Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a ce...
Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria
Sickle cell disease malaria parasitaemia immunoglobulins inflammation haemolysis
2010/1/11
Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a mala...
Body composition in children with sickle cell disease
Sickle cell disease growth nutritional status body composition children African Americans
2016/12/19
Background: Impaired growth, poor nutritional status, and delayed skeletal and sexual maturation are common in children with sickle cell disease (SCD), yet the nature of associated body-compositi...
Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell disease
Energy intake resting metabolic rate sickle cell disease children Jamaica weighed food intake
2016/12/17
Background: A relative energy deficiency consequent to a high resting metabolic rate (RMR) may contribute to growth impairment in persons with homozygous (SS genotype) sickle cell disease (S...
Effect of zinc supplementation on growth and body composition in children with sickle cell disease
Sickle cell disease zinc supplementation growth body composition children
2016/12/17
Background: Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency.Objective: The objective was to determine the effects o...