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Stopping Rules and Data Monitoring in Clinical Trials
stopping rules neyman-pearson bayes bayesian statistical decision statistical inference
2011/9/8
Philosophers subscribing to particular principles of statistical inference need to be aware of the limitations and practical consequences of the statistical approach they endorse. The framework here p...
Statistical Decisions and the Interim Analyses of Clinical Trials
stopping rules neyman-pearson bayes bayesian statistical decision statistical inference
2011/9/8
This paper analyzes statistical decisions during the interim analyses of clinical trials. After some general remarks about the ethical and scientific demands of clinical trials, I introduce the notion...
A STRATEGY OF CLINICAL TOLERANCE FOR THE PREVENTION OF HIV AND AIDS IN CHINA
clinical tolerance health policy HIV/AIDS prevention
2009/1/20
HIV infection and AIDS creates many dilemmas in Chinese AIDS/HIV prevention policy. A strategy of clinical tolerance is proposed to address these dilemmas. The immediate purpose of strategic tolerance...
Clinical Ethics Consultation: Examining how American and Japanese experts analyze an Alzheimer's case
Ethics Consultation American Japanese
2008/11/14
Background
Few comparative studies of clinical ethics consultation practices have been reported. The objective of this study was to explore how American and Japanese experts analyze an Alzheimer's ca...
When research seems like clinical care: a qualitative study of the communication of individual cancer genetic research results
communication clinical
2008/11/14
Background
Research ethicists have recently declared a new ethical imperative: that researchers should communicate the results of research to participants. For some analysts, the obligation is restri...
Clinical research without consent in adults in the emergency setting: a review of patient and public views
adults emergency setting
2008/11/14
Background
In emergency research, obtaining informed consent can be problematic. Research to develop and improve treatments for patients admitted to hospital with life-threatening and debilitating co...
Variation in recruitment across sites in a consent-based clinical data registry: lessons from the Canadian Stroke Network
registry Variation
2008/11/12
Background
In earlier work, we found important selection biases when we tried to obtain consent for participation in a national stroke registry. Recognizing that not all registries will be exempt fro...
Need for enforcement of ethicolegal education – an analysis of the survey of postgraduate clinical trainees
ethicolegal education clinical trainees
2008/11/11
Background
The number of medical lawsuits in Japan was between 14 and 21 each year before 1998, but increased to 24 to 35 per year after 1999. There were 210 lawsuits during this 10-year period. Ther...
Clinical education of ethicists: the role of a clinical ethics fellowship
Clinical education ethicists
2008/11/10
Background
Although clinical ethicists are becoming more prevalent in healthcare settings, their required training and education have not been clearly delineated. Most agree that training and educati...
A decade ago, we reviewed the field of clinical ethics; assessed its progress in research, education, and ethics committees and consultation; and made predictions about the future of the field. In thi...
Singer et al [1] note that despite progress in clinical ethics: (i) most medical schools lack adequate role modelling by a sustainable community of clinicians focussed on the ethical concerns of patie...